The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic
substances and therefore also controls and restricts the entry of therapeutic agents. The …

The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

Epileptic seizures and anxiety crisis are severe conditions that require fast and effective
treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited …

Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …

The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have
been progressively used by neuroscientists during the last several decades. The …

Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

The treatment of central nervous system (CNS) malignancies, including brain cancers, is
limited by a number of obstructions, including the blood-brain barrier (BBB), the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor
prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the …