Sertoli cells, first identified in the adult testis by Enrico Sertoli in the mid-nineteenth century,
are known for their role in fostering male germ cell differentiation and production of mature …

The transcription factor FOXL2 is required in ovarian somatic cells for female fertility.
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …

Temporal transcription profiles of fetal testes with Sertoli cell ablation were examined in 4-
day culture using a diphtheria toxin (DT)-dependent cell knockout system in AMH-TRECK …

Normal ovarian function requires the expression of estrogen receptors α (ESR1) and β
(ESR2) in distinct cell types within the ovary. The double estrogen receptor knockout …

Sertoli cells, omnipresent, somatic cells within the seminiferous tubules of the mammalian
testis are essential to male fertility. Sertoli cells maintain the integrity of the testicular …

Long noncoding RNAs (lncRNAs) are transcribed in complex, overlapping, sense-and
antisense orientations from intronic and intergenic regions of mammalian genomes …

Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands
control key aspects of this process. Transcripts encoding one such ligand, activin A, are …

Sry on the Y-chromosome upregulates Sox9, which in turn upregulates a set of genes such
as Fgf9 to initiate testicular differentiation in the XY gonad. In the absence of Sry expression …

Pigs serve as a robust animal model for the study of human diseases, notably in the context
of disorders of sex development (DSD). This study aims to investigate the phenotypic …

Recent reports suggest that the Hippo signaling pathway regulates testis development,
though its exact roles in Sertoli cell differentiation remain unknown. Here, we examined the …