Covid‐19 and dengue: double punches for dengue‐endemic countries in Asia

H Harapan, M Ryan, B Yohan… - Reviews in medical …, 2021 - Wiley Online Library
Summary The coronavirus disease 2019 (Covid‐19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is an international public health crisis …

Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Platelets in immune response to virus and immunopathology of viral infections

ED Hottz, FA Bozza, PT Bozza - Frontiers in medicine, 2018 - frontiersin.org
Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

ED Hottz, JF Lopes, C Freitas… - Blood, The Journal …, 2013 - ashpublications.org
Dengue is the most frequent hemorrhagic viral disease and re-emergent infection in the
world. Although thrombocytopenia is characteristically observed in mild and severe forms of …

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

RA Campbell, H Schwertz, ED Hottz… - Blood, The Journal …, 2019 - ashpublications.org
Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected
activities in inflammation and infection; whether viral infections upregulate biologically …

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

M Koupenova, O Vitseva, CR MacKay… - Blood, The Journal …, 2014 - ashpublications.org
Viral infections have been associated with reduced platelet counts, the biological
significance of which has remained elusive. Here, we show that infection with …

[HTML][HTML] Platelets: essential components of the immune system

RA Ali, LM Wuescher, RG Worth - Current trends in immunology, 2015 - ncbi.nlm.nih.gov
Platelets are anucleate cell fragments known for their central role in coagulation and
vascular integrity. However, it is becoming increasingly clear that platelets contribute to …

[HTML][HTML] The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication

TF Póvoa, AMB Alves, CAB Oliveira, GJ Nuovo… - PloS one, 2014 - journals.plos.org
Dengue is a public health problem, with several gaps in understanding its pathogenesis.
Studies based on human fatal cases are extremely important and may clarify some of these …

Platelets in pulmonary immune responses and inflammatory lung diseases

EA Middleton, AS Weyrich… - Physiological …, 2016 - journals.physiology.org
Platelets are essential for physiological hemostasis and are central in pathological
thrombosis. These are their traditional and best known activities in health and disease. In …

Dengue virus binding and replication by platelets

AY Simon, MR Sutherland… - Blood, The Journal of …, 2015 - ashpublications.org
Dengue virus (DENV) infection causes∼ 200 million cases of severe flulike illness annually,
escalating to life-threatening hemorrhagic fever or shock syndrome in∼ 500 000. Although …