Approaches to peripheral nerve repair: generations of biomaterial conduits yielding to replacing autologous nerve grafts in craniomaxillofacial surgery

R Gaudin, C Knipfer, A Henningsen… - BioMed research …, 2016 - Wiley Online Library
Peripheral nerve injury is a common clinical entity, which may arise due to traumatic,
tumorous, or even iatrogenic injury in craniomaxillofacial surgery. Despite advances in …

Experimental strategies to promote spinal cord regeneration—an integrative perspective

JM Schwab, K Brechtel, CA Mueller, V Failli… - Progress in …, 2006 - Elsevier
Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …

Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

Y Ogawa, K Sawamoto, T Miyata… - Journal of …, 2002 - Wiley Online Library
Neural progenitor cells, including neural stem cells, are a potential expandable source of
graft material for transplantation aimed at repairing the damaged CNS. Here we present the …

The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

KI Park, YD Teng, EY Snyder - Nature biotechnology, 2002 - nature.com
Hypoxic-ischemic injury is a prototype for insults characterized by extensive tissue loss.
Seeding neural stem cells (NSCs) onto a polymer scaffold that was subsequently implanted …

Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury

P Riess, C Zhang, KE Saatman, HL Laurer… - …, 2002 - journals.lww.com
OBJECTIVE: Using the neural stem cell (NSC) clone C17. 2, we evaluated the ability of
transplanted murine NSCs to attenuate cognitive and neurological motor deficits after …

Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells

C Meier, J Middelanis, B Wasielewski, S Neuhoff… - Pediatric …, 2006 - nature.com
Brain damage around birth may cause lifelong neurodevelopmental deficits. We examined
the therapeutic potential of human umbilical cord blood–derived mononuclear cells …

Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors

J Lladó, C Haenggeli, NJ Maragakis, EY Snyder… - Molecular and Cellular …, 2004 - Elsevier
Besides their capacity to give rise to neurons and/or glia, neural stem cells (NSCs) appear to
inherently secrete neurotrophic factors beneficial to injured neurons. To test this potential …

Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats

JUN Namiki, A Kojima, CH Tator - Journal of neurotrauma, 2000 - liebertpub.com
This study examined whether continuous intramedullary infusion of brain-derived
neurotrophic factor (BDNF), nerve growth factor (NGF), or neurotrophin-3 (NT-3) had either …

Establishment and Properties of Neural Stem Cell Clones: Plasticity In Vitro and In Vivo

AL Vescovi, EY Snyder - Brain pathology, 1999 - Wiley Online Library
The study of the basic physiology of the neural precursors generated during brain
development is driven by two inextricably linked goals. First, such knowledge is instrumental …

Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: evidence from engraftment of neurotrophin-3-expressing stem cells in …

KI Park, BT Himes, PE Stieg, A Tessler, I Fischer… - Experimental …, 2006 - Elsevier
Previously, we reported that, when clonal neural stem cells (NSCs) were transplanted into
brains of postnatal mice subjected to unilateral hypoxic–ischemic (HI) injury (optimally 3–7 …