Perspective for discovery of small molecule IL-6 inhibitors through study of structure–activity relationships and molecular docking

H Nada, A Sivaraman, Q Lu, K Min, S Kim… - Journal of Medicinal …, 2023 - ACS Publications
Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a key role in the pathogenesis
and physiology of inflammatory and autoimmune diseases, such as coronary heart disease …

Giant cell arteritis: an updated review

A Kawasaki, V Purvin - Acta ophthalmologica, 2009 - Wiley Online Library
Giant cell arteritis (GCA) is the most common primary vasculitis of adults. The incidence of
this disease is practically nil in the population under the age of 50 years, then rises …

[HTML][HTML] The role of integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in macrophage fusion

NP Podolnikova, YS Kushchayeva, YF Wu… - The American journal of …, 2016 - Elsevier
The subfamily of β2 integrins is implicated in macrophage fusion, a hallmark of chronic
inflammation. Among β2 family members, integrin Mac-1 (α M β 2, CD11b/CD18) is …

[HTML][HTML] The treatment of giant cell arteritis

JA Fraser, CM Weyand, NJ Newman… - Reviews in …, 2008 - ncbi.nlm.nih.gov
Although giant cell arteritis (GCA) is a well-known vasculitis sensitive to corticosteroid-
mediated immunosuppression, numerous issues of long-term therapeutic management …

Giant cell arteritis: early diagnosis is key

IF Baig, AR Pascoe, A Kini, AG Lee - Eye and Brain, 2019 - Taylor & Francis
Giant cell arteritis (GCA) is an inflammatory vasculitis typically affecting elderly that can
potentially cause vision loss. Studies have demonstrated that early recognition and initiation …

Cardiovascular involvement in systemic rheumatic diseases: an integrated view for the treating physicians

KS Lee, A Kronbichler, M Eisenhut, KH Lee… - Autoimmunity Reviews, 2018 - Elsevier
Systemic autoimmune diseases can affect various kinds of organs including the kidney, the
skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic …

Cardiac manifestations of rheumatological conditions: a narrative review

MB Owlia… - International …, 2012 - Wiley Online Library
Cardiovascular diseases are common in systemic rheumatologic diseases. They can be
presented at the time of diagnosis or after diagnosis. The cardiac involvements can be the …

Unraveling the links between chronic inflammation, autoimmunity, and spontaneous cervicocranial arterial dissection

H Li, S Xu, B Xu, Y Zhang, J Yin, Y Yang - Journal of Clinical Medicine, 2023 - mdpi.com
Advances in imaging techniques have led to a rise in the diagnosis of spontaneous
cervicocranial arterial dissection (SCCAD), which is now considered a common cause of …

Cardiovascular magnetic resonance in the diagnosis and management of cardiac and vascular involvement in the systemic vasculitides

SI Mavrogeni, T Dimitroulas… - Current Opinion in …, 2019 - journals.lww.com
CMR due to its great versatility gives valuable information about cardiac function, perfusion,
type of fibrosis and vascular integrity that may significantly contribute to treatment decisions …

Treatment of giant cell arteritis

SJ Almarzouqi, ML Morgan, AG Lee - Current Opinion in …, 2015 - journals.lww.com
Treatment of giant cell arteritis : Current Opinion in Ophthalmology Treatment of giant cell
arteritis : Current Opinion in Ophthalmology Log in or Register Subscribe to journalSubscribe …