Aurora is the name given to a family of highly conserved protein kinases with essential roles
in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals …

Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …

Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an
attractive drug target in numerous maladies that range from heart disease to …

Mitotic cells face the challenging tasks of linking kinetochores to growing and shortening
microtubules and actively regulating these dynamic attachments to produce accurate …

Merotelic kinetochore orientation is a misattachment in which a single kinetochore binds
microtubules from both spindle poles rather than just one and can produce anaphase …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

The kinetochore is a control module that both powers and regulates chromosome
segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably …

How kinetochore proteins form a dynamic interface with microtubules is largely unknown. In
budding yeast, the 10-protein Dam1 complex is an Aurora kinase target that plays essential …

The coupling of kinetochores to dynamic spindle microtubules is crucial for chromosome
positioning and segregation, error correction, and cell cycle progression. How these …