Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis

H Han, Y Jiang, M Wang, M Melaku, L Liu… - Critical reviews in …, 2023 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders
in humans, partly because it is closely related to metabolic disorders of the liver with …

Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): A concise review

N Nasiri-Ansari, T Androutsakos, CM Flessa, I Kyrou… - Cells, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies

YA Lee, SL Friedman - Journal of Internal Medicine, 2022 - Wiley Online Library
Non‐alcoholic fatty liver disease is comprised of either simple steatosis (non‐alcoholic fatty
liver) or a more advanced inflammatory and fibrogenic stage (non‐alcoholic steatohepatitis …

[HTML][HTML] Smart drug delivery systems for precise cancer therapy

X Wang, C Li, Y Wang, H Chen, X Zhang, C Luo… - … Pharmaceutica Sinica B, 2022 - Elsevier
Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort
has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics …

Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Nonalcoholic fatty liver disease: current therapies and future perspectives in drug delivery

I Domingues, IA Leclercq, A Beloqui - Journal of Controlled Release, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …

Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐Mediated TGF‐β1/Smad …

MX Liu, L Xu, YT Cai, RJ Wang, YY Gu… - Advanced …, 2023 - Wiley Online Library
Hypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐
1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver …

Red blood cell inspired strategies for drug delivery: emerging concepts and new advances

E Zhang, P Phan, HA Algarni, Z Zhao - Pharmaceutical Research, 2022 - Springer
In the past five decades, red blood cells (RBCs) have been extensively explored as drug
delivery systems due to their distinguishing potential in modulating the pharmacokinetic …

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine

R Sun, J Dai, M Ling, L Yu, Z Yu, L Tang - Journal of Nanobiotechnology, 2022 - Springer
As a natural product with various biological activities, triptolide (TP) has been reported in
anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic …