The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues
(blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological …

Background and Objectives Real-time quaking-induced conversion (RT-QuIC) assay detects
misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies …

Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to
detect α-synuclein aggregates. Studies in Parkinson's disease (PD) and isolated REM-sleep …

Exosomes, which are small extracellular vehicles produced by a variety of cell types, have
emerged as key actors in intercellular communication due to their ability to transport a …

Background Skin biopsy is a potential tool for the premortem confirmation of an α‐
synucleinopathy. Objective The aim was to assess the aggregation assay real‐time quaking …

Rapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of
Parkinson's disease (PD), but the pathogenetic mechanism involved in RBD remains largely …

We recently proposed a new disease model of Parkinson's disease–the a-Synuclein Origin
site and Connectome model. The model posits that the initial pathology starts either in the …

Abstract α-Synuclein is a protein that mainly exists in the presynaptic terminals. Abnormal
folding and accumulation of α-synuclein are found in several neurodegenerative diseases …

Introduction Idiopathic REM-sleep behavior disorder (iRBD) is considered the most specific
prodromal marker of Parkinson's disease (PD). With the need to improve early detection of …

α-突触核蛋白是一种主要存在于突触前末端的蛋白. 在包括帕金森病在内的多种神经退行性疾病
中, 已发现了α-突触核蛋白存在异常折叠和积聚. 聚集和高度磷酸化的α-突触核蛋白是大脑中 …