Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active
against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low …

Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is
known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential …

Breast cancer is the leading cause of cancer death in women. Chemotherapy is regarded as
the most essential strategy in inhibiting the proliferation of tumor cells. Paclitaxel is a widely …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

Introduction: Metastatic breast cancer is one of the most devastating cancers that have no
cure. Many therapeutic and diagnostic strategies have been extensively studied in the past …

Paclitaxel (PTX) is an effective anticancer chemical with a broad spectrum that was primarily
obtained from a curative shrub, specifically the bark of Taxus brevifolia tree. It belongs to a …

Anthracyclines (doxorubicin, daunorubicin, and idarubicin) are very effective
chemotherapeutic drugs to treat many cancers; however, the development of multiple drug …

Application of nanotechnology in the medical field (ie, nanomedicine) plays an important
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …