Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis

J Bonne Køhler, C Jers, M Senissar, L Shi… - FEBS …, 2020 - Wiley Online Library
Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …

Tyrosine phosphorylation as a widespread regulatory mechanism in prokaryotes

LJ Getz, CS Runte, JK Rainey… - Journal of Bacteriology, 2019 - Am Soc Microbiol
Phosphorylation events modify bacterial and archaeal proteomes, imparting cells with rapid
and reversible responses to specific environmental stimuli or niches. Phosphorylated …

Baicalein suppresses NLRP3 and AIM2 inflammasome-mediated pyroptosis in macrophages infected by Mycobacterium tuberculosis via induced autophagy

B Ning, J Shen, F Liu, H Zhang, X Jiang - Microbiology Spectrum, 2023 - Am Soc Microbiol
Mycobacterium tuberculosis (Mtb) continues to pose a significant threat to global health
because it causes granulomas and systemic inflammatory responses during active …

Phosphorylation of CFP10 modulates Mycobacterium tuberculosis virulence

B Malakar, K Chauhan, P Sanyal, S Naz, H Kalam… - Mbio, 2023 - Am Soc Microbiol
Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune
mechanisms and, therefore, are critical for establishing infection and pathogenesis …

The unique N-terminal region of Mycobacterium tuberculosis sigma factor A plays a dominant role in the essential function of this protein

B Singha, D Behera, MZ Khan, NK Singh… - Journal of Biological …, 2023 - ASBMB
SigA (σ A) is an essential protein and the primary sigma factor in Mycobacterium
tuberculosis (Mtb). However, due to the absence of genetic tools, our understanding of the …

Andrographolide Suppresses Pyroptosis in Mycobacterium tuberculosis-Infected Macrophages via the microRNA‐155/Nrf2 Axis

Y Fu, J Shen, F Liu, H Zhang, Y Zheng… - … medicine and cellular …, 2022 - Wiley Online Library
Tuberculosis (TB) remains a leading threat to public health worldwide with Mycobacterium
tuberculosis (Mtb) infections causing long‐term abnormal and excessive inflammatory …

The Mycobacterium tuberculosis protein O-phosphorylation landscape

A Frando, V Boradia, M Gritsenko, C Beltejar… - Nature …, 2023 - nature.com
Bacterial phosphosignalling has been synonymous with two-component systems and their
histidine kinases, but many bacteria, including Mycobacterium tuberculosis (Mtb), also code …

LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

P Kaur, M Rausch, B Malakar, U Watson… - Nature …, 2019 - nature.com
Abstract The Mycobacterium tuberculosis kinase PknB is essential for growth and survival of
the pathogen in vitro and in vivo. Here we report the results of our efforts to elucidate the …

Dissecting host-pathogen interactions in TB using systems-based omic approaches

K Borah, Y Xu, J McFadden - Frontiers in immunology, 2021 - frontiersin.org
Tuberculosis (TB) is a devastating infectious disease that kills over a million people every
year. There is an increasing burden of multi drug resistance (MDR) and extensively drug …

Regulation of protein post-translational modifications on metabolism of actinomycetes

CF Sun, YQ Li, XM Mao - Biomolecules, 2020 - mdpi.com
Protein post-translational modification (PTM) is a reversible process, which can dynamically
regulate the metabolic state of cells through regulation of protein structure, activity …