The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53
suppresses tumorigenesis by transcriptionally regulating a network of target genes that play …

Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …

Lung cancer is the leading cause of cancer deaths worldwide. Mutations in the tumour
suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and are linked to …

Gendicine (recombinant human p53 adenovirus), developed by Shenzhen SiBiono
GeneTech Co. Ltd., was approved in 2003 by the China Food and Drug Administration …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

With the development of radiotherapeutic oncology, computer technology and medical
imaging technology, radiation therapy has made great progress. Research on the impact …

Highlights•p53 responses to acute DNA damage signals are dispensable for tumor
suppression.•p53 transcriptional activity is critical for tumor suppression.•p53 responds to …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of
approximately 9%. An improved understanding of PDAC initiation and progression is …

Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious
treatment modalities. Elucidation of signaling mechanisms that will lead to the identification …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …