Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and
poor tissue perfusion. These features are proposed to limit the access of therapies to …

CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that
includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 …

Connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) are prototypical
members of the CCN family which also contains nephroblastoma overexpressed (NOV) and …

Cyr61 is a heparin-binding, extracellular matrix-associated protein of the CCN family, which
also includes connective tissue growth factor, Nov, WISP-1, WISP-2, and WISP-3. Cyr61 is …

We recently reported the cloning of WWOX, a gene that maps to the common fragile site
FRA16D region in chromosome 16q23. 3-24.1. It was observed that the genomic area …

To gain insight into the role of the CCN genes in human breast carcinomas, we quantified
connective tissue growth factor (CTGF), WISP-1, CYR61, and human NOV (NOVH) mRNA …

Abstract mTORC2 is a multimeric kinase composed of the mammalian target of rapamycin
kinase (mTOR), mLST8, mSin1, and rictor. The complex is insensitive to acute rapamycin …