Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Coumarin derivatives were recently shown to constitute a totally new class of inhibitors of the
zinc metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1), being hydrolyzed within the CA …

Coumarins are of many different structures. They constitute an important class of
pharmacological agents possessing a range of different physiological activities including …

Coumarins are oxygen-containing molecules with specific benzopyrone nucleus. Different
coumarins are identified as antineurodegeneratives, anticoagulants, antioxidants …

Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel
condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was
carried out starting from 7-formyl-coumarin. The compounds were tested in vivo for their anti …

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative
properties of recently developed synthetic coumarin derivatives among which two …

Serine proteases are attractive targets for the design of enzyme inhibitors since they are
involved in the etiology of several diseases. Within the class of serine proteases, HLE is one …