RNA-binding proteins in human genetic disease

F Gebauer, T Schwarzl, J Valcárcel… - Nature Reviews …, 2021 - nature.com
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

miRNA dosage control in development and human disease

Y Cui, Y Qi, L Ding, S Ding, Z Han, Y Wang, P Du - Trends in Cell Biology, 2024 - cell.com
In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

The intricate balance between microRNA‐induced mRNA decay and translational repression

P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …

Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions

JK Nussbacher, R Tabet, GW Yeo, C Lagier-Tourenne - Neuron, 2019 - cell.com
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

MicroRNAs: small RNAs with a big role in gene regulation

L He, GJ Hannon - Nature reviews genetics, 2004 - nature.com
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …

[HTML][HTML] The role of microRNAs in human diseases

AM Ardekani, MM Naeini - Avicenna journal of medical …, 2010 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …

[HTML][HTML] A mammalian microRNA expression atlas based on small RNA library sequencing

P Landgraf, M Rusu, R Sheridan, A Sewer, N Iovino… - Cell, 2007 - cell.com
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …