RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
The molecular biology of FMRP: new insights into fragile X syndrome
JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …
miRNA dosage control in development and human disease
In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …
The widespread regulation of microRNA biogenesis, function and decay
J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
The intricate balance between microRNA‐induced mRNA decay and translational repression
P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …
Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
MicroRNAs in development and disease
D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
MicroRNAs: small RNAs with a big role in gene regulation
MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …
sequence-specific manner. The two founding members of the microRNA family were …
[HTML][HTML] The role of microRNAs in human diseases
AM Ardekani, MM Naeini - Avicenna journal of medical …, 2010 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …
translational repression and gene silencing and are found in all eukaryotic cells …
[HTML][HTML] A mammalian microRNA expression atlas based on small RNA library sequencing
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …
translation of fully or partially sequence-complementary target mRNAs. In order to identify …