Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …

Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

During disease progression from primary towards metastatic prostate cancer (PCa), and in
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …

Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective
effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the …

Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic
status of gastric cancer cells has not translated into effective prognostic or therapeutic …

Extracellular vesicles (EVs) are newly appreciated regulators of tissue homeostasis and a
means of intercellular communication. Reports have investigated the role of EVs and their …

Extracellular vesicles (EVs), especially exosomes, are now well recognized as major ways
by which cancer cells interact with each other and stromal cells. The meaningful messages …

Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that
are associated with fractures, disability, and increased mortality. Within the bone metastatic …

Bone formation or regeneration requires the recruitment, proliferation, and osteogenic
differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is …

Regenerative medicine aims to promote the replacement of tissues lost to damage or
disease. While positive outcomes have been observed experimentally, challenges remain in …