Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in
nicotinamide adenine dinucleotide biosynthesis. In the extracellular compartment, it exhibits …

The Notch family consists of four highly conserved transmembrane receptors. The release of
the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is …

Notch signaling determines and reinforces cell fate in bilaterally symmetric multicellular
eukaryotes. Despite the involvement of Notch in many key developmental systems, human …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis …

Activating mutations of NOTCH1 (a well-known oncogene in T-cell acute lymphoblastic
leukemia) are present in∼ 4–13% of chronic lymphocytic leukemia (CLL) cases, where they …

The role of monocytes/macrophages in the development and progression of chronic
lymphocytic leukemia (CLL) is poorly understood. Transcriptomic analyses show that …