Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Collagen VI represents a remarkable extracellular matrix molecule, and in the past few
years, studies of this molecule have revealed its involvement in a wide range of tissues and …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

Age-related changes in cardiac homeostasis can be observed at the cellular, extracellular,
and tissue levels. Progressive cardiomyocyte hypertrophy, inflammation, and the gradual …