Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The voltage-gated calcium (Cav) channels convert membrane electrical signals to
intracellular Ca2+-mediated events. Among the ten subtypes of Cav channel in mammals …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are
the molecular targets for drugs and disease mutations, but the structural basis for their …

Among the ten subtypes of mammalian voltage-gated calcium (Ca v) channels, Ca v 3.1–Ca
v 3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Stimulation of immune cells causes depletion of Ca2+ from endoplasmic reticulum (ER)
stores, thereby triggering sustained Ca2+ entry through store-operated Ca2+ release …

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in
retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct …

Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the
molecules comprising the Ca2+-permeation pathway in sperm motility are poorly …