Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …

Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …

YES-associated protein (YAP), a critical actor of the mammalian Hippo signaling pathway
involved in diverse biological events, has gained increased recognition as a cellular factor …

Activation of the endoplasmic reticulum (ER)–resident adaptor protein STING, a component
of a cytosolic DNA–sensing pathway, induces the transcription of genes encoding type I …

Stimulator of interferon (IFN) genes (STING) was recently pinpointed as an antiviral innate
immune factor during the infection of RNA viruses. Porcine reproductive and respiratory …

Persistent infection and tumorigenesis by papillomaviruses (PVs) require viral manipulation
of various cellular processes, including those involved in innate immune responses. The …

STING is a critical adaptor protein in the cGAS-mediated DNA-sensing innate immune
pathway. Binding of the second messenger cGAMP generated by cGAS to STING induces …

Hantaan virus (HTNV), the prototype virus of hantavirus, could escape innate immunity by
restraining type I interferon (IFN) responses. It is largely unknown whether there existed …