Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism that
typifies all eukaryotes examined to date. NMD surveys newly synthesized mRNAs and …

The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

The X-linked Duchenne and Becker muscular dystrophies (DMD and BMD) are allelic
disorders occurring due to mutations in the DMD gene, which consists of 79 exons encoding …

Nonsense suppression therapy encompasses approaches aimed at suppressing translation
termination at in-frame premature termination codons (PTCs, also known as nonsense …

Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect
termination of translation and generation of non-functional, truncated proteins. Translational …

Eukaryotic cells utilize various RNA quality control mechanisms to ensure high fidelity of
gene expression, thus protecting against the accumulation of nonfunctional RNA and the …

Ten percent of inherited diseases are caused by premature termination codon (PTC)
mutations that lead to degradation of the mRNA template and to the production of a non …

ATM, mutation of which causes Ataxia telangiectasia, has emerged as a cardinal
multifunctional protein kinase during past two decades as evidenced by various studies from …

Ataxia-telangiectasia mutated (ATM) is a high molecular weight protein serine/threonine
kinase that plays a central role in the maintenance of genomic integrity by activating cell …

About 11% of all human disease-associated gene lesions are nonsense mutations, resulting
in the introduction of an in-frame premature translation-termination codon (PTC) into the …