Mitochondrial genetics through the lens of single-cell multi-omics
Mitochondria carry their own genetic information encoding for a subset of protein-coding
genes and translational machinery essential for cellular respiration and metabolism. Despite …
genes and translational machinery essential for cellular respiration and metabolism. Despite …
[HTML][HTML] Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has
been linked to lifespan in nonhuman species and recently demonstrated to occur in rare …
been linked to lifespan in nonhuman species and recently demonstrated to occur in rare …
[HTML][HTML] Mitochondrial control of lymphocyte homeostasis
YF Yazicioglu, RJ Mitchell, AJ Clarke - Seminars in Cell & Developmental …, 2024 - Elsevier
Mitochondria play a multitude of essential roles within mammalian cells, and understanding
how they control immunity is an emerging area of study. Lymphocytes, as integral cellular …
how they control immunity is an emerging area of study. Lymphocytes, as integral cellular …
T cell activation contributes to purifying selection against the MELAS‐associated m. 3243A> G pathogenic variant in blood
MA Walker, S Li, KJ Livak, A Karaa… - Journal of Inherited …, 2024 - Wiley Online Library
T cells have been shown to maintain a lower percentage (heteroplasmy) of the pathogenic
m. 3243A> G variant (MT‐TL1, associated with maternally inherited diabetes and deafness …
m. 3243A> G variant (MT‐TL1, associated with maternally inherited diabetes and deafness …
[HTML][HTML] Single-Cell Mitochondrial DNA Sequencing: Methodologies and Applications
Mitochondria play a pivotal role in cellular energetics, metabolism, and various regulatory
processes. Their dysregulation is implicated in numerous diseases. Traditional population …
processes. Their dysregulation is implicated in numerous diseases. Traditional population …
Frequencies and spectra of aflatoxin B1-induced mutations in liver genomes of NEIL1-deficient mice as revealed by duplex sequencing
IG Minko, MM Luzadder, VL Vartanian… - NAR Molecular …, 2024 - academic.oup.com
Increased risk for the development of hepatocellular carcinoma (HCC) is driven by a number
of etiological factors including hepatitis viral infection and dietary exposures to foods …
of etiological factors including hepatitis viral infection and dietary exposures to foods …
Pathogenic mitochondrial DNA point mutations in the immune system:'A tale of two cities'
J Zhang - 2024 - search.proquest.com
High levels of heteroplasmic pathogenic mtDNA mutations in mitochondrial tRNA (mt-tRNA)
genes can severely disrupt mitochondrial translation and oxidative phosphorylation, leading …
genes can severely disrupt mitochondrial translation and oxidative phosphorylation, leading …