The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Advanced glycation end products (AGEs) are substances composed of amino groups of
proteins and reducing sugars. The initial and propagation phases of the glycation process …

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Background—Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) in the
cardiovascular system. The deficiency of CSE in mice leads to a decreased endogenous …

The glyoxalase system is a ubiquitous enzymatic network which plays important roles in
biological life. It consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced …

Diabetes was the first disease state where evidence emerged for increased formation of
methylglyoxal. Metabolism of methylglyoxal by the glyoxalase system has been linked to the …

Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates
of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the …

We are currently in the midst of an epidemic of metabolic disorders, which may, in part, be
explained by excess fructose intake. This theory is supported by epidemiological …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …