Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

The prevalence of obesity and associated diseases has reached pandemic levels. Obesity is
often associated with overnutrition and a sedentary lifestyle, but clearly other factors also …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may
represent a new biosignaling paradigm. According to the mode of biogenesis, size and …

Accumulating evidence suggests that adversities at critical periods in early life, both pre-and
postnatal, can lead to neuroendocrine perturbations, including hypothalamic-pituitary …

Microglia are the resident immune cells of the central nervous system contributing
substantially to health and disease. There is increasing evidence that inflammatory microglia …

Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …

The herbicide glyphosate has been shown to promote the epigenetic transgenerational
inheritance of pathology and disease in subsequent great-grand offspring (F3 generation) …