[HTML][HTML] Animal models of obesity and diabetes mellitus

M Kleinert, C Clemmensen, SM Hofmann… - Nature Reviews …, 2018 - nature.com
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Central nervous system control of glucose homeostasis: a therapeutic target for type 2 diabetes?

Z Mirzadeh, CL Faber… - Annual review of …, 2022 - annualreviews.org
Historically, pancreatic islet beta cells have been viewed as principal regulators of glycemia,
with type 2 diabetes (T2D) resulting when insulin secretion fails to compensate for …

Hepatic adverse effects of fructose consumption independent of overweight/obesity

A Schultz, D Neil, MB Aguila… - International journal of …, 2013 - mdpi.com
The chronic intake of fructose has been linked to insulin resistance, obesity, dyslipidemia
and nonalcoholic fatty liver disease (NAFLD), which in turn, may progress to nonalcoholic …

Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice

S Kozuki, M Kabata, S Sakurai, K Iwaisako… - Communications …, 2023 - nature.com
The maternal liver is challenged by metabolic demands throughout pregnancy. However,
hepatocyte dynamics and their physiological significance in pregnancy remain unclear …

Fructose, pregnancy and later life impacts

TRH Regnault, S Gentili, O Sarr… - Clinical and …, 2013 - Wiley Online Library
Fructose is an increasingly common constituent of the Westernized diet due to cost and
production efficiencies. Although an integral component of our pre‐industrial revolution diet …

Nutritional regulation of glucokinase: a cross-species story

S Panserat, N Rideau, S Polakof - Nutrition research reviews, 2014 - cambridge.org
The glucokinase (GK) enzyme (EC 2.7. 1.1.) is essential for the use of dietary glucose
because it is the first enzyme to phosphorylate glucose in excess in different key tissues …

Large animal models in the study of gynecological diseases

M Cui, Y Liu, X Men, T Li, D Liu, Y Deng - Frontiers in Cell and …, 2023 - frontiersin.org
Gynecological diseases are a series of diseases caused by abnormalities in the female
reproductive organs or breast, which endanger women's fertility and even their lives …

Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis

AA Yuruk, R Nergiz-Unal - Lipids in health and disease, 2017 - Springer
Background Maternal dietary choices throughout preconception, pregnancy, and lactation
irreversibly affect the development of fetal tissues and organs, known as fetal programming …

Prenatal hyperglycemia exposure and cellular stress, a sugar-coated view of early programming of metabolic diseases

J Tozour, F Hughes, A Carrier, D Vieau, F Delahaye - Biomolecules, 2020 - mdpi.com
Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422
million in 2014 (World Health Organization). This distressing rise in diabetes also affects …

Carvacrol modulates antioxidant enzymes, DNA integrity, and apoptotic markers in zearalenone-exposed fetal rat liver

M Eleyan, MR Zughbur, M Hussien… - Drug and Chemical …, 2024 - Taylor & Francis
Maternal exposure to zearalenone (ZEA), a mycotoxin, can impact fetal liver development.
This study investigated the protective effects of carvacrol (CRV) against ZEA-induced fetal …