Plant kunitz inhibitors and their interaction with proteases: Current and potential pharmacological targets

CR Bonturi, AB Silva Teixeira, VM Rocha… - International Journal of …, 2022 - mdpi.com
The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review

AM de Souza Nascimento… - Journal of Enzyme …, 2022 - Taylor & Francis
This systematic review (SR) aimed to gather studies describing the antibacterial action
mechanisms and mode of trypsin inhibitors. The review protocol was registered …

[HTML][HTML] ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and …

NMS Araújo, LP Dias, HPS Costa, DOB Sousa… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Cassia leiandra is an Amazonian plant species that is used popularly for the treatment of
mycoses. Recently, a protease inhibitor, named ClTI, with insecticidal activity against Aedes …

[HTML][HTML] Adepamycin: design, synthesis and biological properties of a new peptide with antimicrobial properties

LH de Oliveira Almeida, CFR de Oliveira… - Archives of Biochemistry …, 2020 - Elsevier
Antimicrobial peptides (AMP) are molecules with a broad spectrum of activities that have
been identified in most living organisms. In addition, synthetic AMPs designed from natural …

Role of membrane sterol and redox system in the anti-candida activity reported for Mo-CBP2, a protein from Moringa oleifera seeds

JX da Silva Neto, HPS da Costa… - International journal of …, 2020 - Elsevier
Plant proteins are emerging as an alternative to conventional treatments against
candidiasis. The aim of this study was to better understand the mechanism of action of Mo …

Machaerium acutifolium lectin alters membrane structure and induces ROS production in Candida parapsilosis

LP Dias, ALE Santos, NMS Araújo, RRS Silva… - International Journal of …, 2020 - Elsevier
Lectins are a group of widely distributed and structurally heterogeneous proteins of
nonimmune origin. These proteins have the ability to interact with glycans present on cell …

[HTML][HTML] Immobilization of antimicrobial trypsin inhibitors onto cashew gum polysaccharide/PVA films

MV Cruz, AC Jacobowski, MLR Macedo… - International journal of …, 2019 - Elsevier
In this work, films produced by blending cashew gum polysaccharide (CGP) with PVA were
used as support for immobilization of trypsin inhibitors with antimicrobial activity obtained …

DAKS1, a Kunitz Scaffold Peptide from the Venom Gland of Deinagkistrodon acutus Prevents Carotid-Artery and Middle-Cerebral-Artery Thrombosis via Targeting …

Z Jia, Y Liu, X Ji, Y Zheng, Z Li, S Jiang, H Li, Y Kong - Pharmaceuticals, 2021 - mdpi.com
Scaffold-based peptides (SBPs) are fragments of large proteins that are characterized by
potent bioactivity, high thermostability, and low immunogenicity. Some SBPs have been …

ClCPI, a cysteine protease inhibitor purified from Cassia leiandra seeds has antifungal activity against Candida tropicalis by inducing disruption of the cell surface

IRS Melo, LP Dias, NMS Araújo, IM Vasconcelos… - International journal of …, 2019 - Elsevier
Infections caused by Candida tropicalis have increased significantly worldwide in parallel
with resistance to antifungal drugs. To overcome resistance novel drugs have to be …

[HTML][HTML] Exploration of anti-insect potential of trypsin inhibitor purified from seeds of Sapindus mukorossi against Bactrocera cucurbitae

D Singh, AK Kesavan, SK Sohal - Scientific Reports, 2019 - ncbi.nlm.nih.gov
Peptidase inhibitors (PIs) are defense proteins of plants which are active against gut
peptidases of different insects. Sapindus mukorossi was identified as a source of bioactive …