Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to
maintain and remodel tissue architecture. Their substrates represent an astounding variety …

purpose. To evaluate production and activity of metalloproteinase (MMP)-9 on the ocular
surface of patients with dysfunctional tear syndrome (DTS) and determine any correlation …

purpose. To investigate whether exposure of human corneal epithelial cells to hyperosmotic
stress activates the c-Jun NH 2-terminal kinase (JNK) stress-activated protein kinase (SAPK) …

Purpose: To investigate the expression of proteases, proteolytic activity and cytokines in the
tear film of people with keratoconus. Methods: Basal tears from people with keratoconus …

Background Proteases, protease activity and inflammatory molecules in tears have been
found to be relevant in the pathogenesis of keratoconus. We sought to determine the …

PURPOSE: To report corneal complications associated with topical nonsteroidal anti-
inflammatory drugs (NSAIDs). DESIGN: Retrospective, noncomparative interventional case …

We studied the role of the matrix metalloproteinase gelatinase B (gelB; MMP-9) in epithelial
regeneration using the gelB-deficient mouse. We report the novel finding that, in contrast to …

In mammals, penetrating injuries typically heal by deposition of fibrotic “repair tissue” that
fills and seals wounds but does not restore normal function. Excessive deposition of fibrotic …

The matrix metalloproteinases, MMP-2 and MMP-9, are known to be critical extracellular-
remodeling enzymes in wound healing and other diseases of the ocular surface. This study …