Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Major features of the transcellular signaling mechanism responsible for endothelium-
dependent regulation of vascular smooth muscle tone are unresolved. We identified local …

Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

Varicose veins are a common venous disease of the lower extremity. Although the
mechanisms and determinants in the development of varicosities are not clearly defined …

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …

ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago.
Reconstitution of KATP channel activity by coexpression of members of the pore-forming …

The cerebrovascular endothelium exerts a profound influence on cerebral vessels and
cerebral blood flow. This review summarizes current knowledge of various dilator and …