Stimuli‐Responsive antibacterial materials: molecular structures, design principles, and biomedical applications

X Wang, M Shan, S Zhang, X Chen, W Liu… - Advanced …, 2022 - Wiley Online Library
Infections are regarded as the most severe complication associated with human health,
which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic …

Perspectives about self-immolative drug delivery systems

RV Gonzaga, LA do Nascimento, SS Santos… - Journal of …, 2020 - Elsevier
Self-immolative drug delivery system is one of the delivery systems, which have drawn
attention, in recent research, highlighting the improvement they generate in drug selectivity …

Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr.

XY Ding, JR Wen, WY Lin, GY Huang, Q Feng, L Duan… - Phytochemistry, 2023 - Elsevier
Two previously undescribed phloroglucinol derivatives [(±) evolephloroglucinols A and B],
five unusual coumarins [evolecoumarins A and B and (±) evolecoumarins C–E], and one …

Naked-eye sensing and target-guiding treatment of bacterial infection using pH-tunable multicolor luminescent lanthanide-based hydrogel

Q Zhou, X Dong, B Zhang, X Zhang, K Ou… - Journal of Colloid and …, 2022 - Elsevier
In this work, a pH-tunable multicolor luminescent lanthanide-based hydrogel (CS/DEX/CP)
was prepared based on lanthanide coordination polymer (CP), dextran aldehyde (DEX) and …

Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections

T Li, X He, W Tao, R Zhang, Q He, H Gong, Y Liu… - European Journal of …, 2024 - Elsevier
Infections caused by drug-resistant bacteria have become a new challenge in infection
treatment, gravely endangering public health. Chloramphenicol (CL) is a well-known …

A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides

E Ermini, A Brai, E Cini, F Finetti, G Giannini… - Chemical …, 2024 - pubs.rsc.org
A stimuli-sensitive linker is one of the indispensable components of prodrugs for cancer
therapy as it covalently binds the drug and releases it upon external stimulation at the …

Fluoroquinolones' biological activities against laboratory microbes and cancer cell lines

GARY Suaifan, AAM Mohammed, BA Alkhawaja - Molecules, 2022 - mdpi.com
Development of novel derivatives to rein in and fight bacteria have never been more
demanding, as microbial resistance strains are alarmingly increasing. A multitude of new …

Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells

S Wang, X Wu, Y Zhang, D Zhang, B Xie… - Organic & …, 2021 - pubs.rsc.org
Hypoxia is a pathological hallmark of solid tumors. Detection of hypoxia is therefore of great
interest for tumor diagnosis and treatment. As a well-established biomarker of hypoxia …

Site-Specific Antimicrobial Activity of a Dual-Responsive Ciprofloxacin Prodrug

CL Ross, A Lawer, KJ Sircombe, D Pletzer… - Journal of Medicinal …, 2024 - ACS Publications
Bacterial infections create distinctive microenvironments with a unique mix of metabolites
and enzymes compared with healthy tissues that can be used to trigger the activation of …

Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation

K Liu, T Xiao, H Yang, M Chen, Q Gao… - RSC Medicinal …, 2023 - pubs.rsc.org
It is of great importance to develop new strategies to combat antibiotic resistance. Our lab
has discovered halogenated phenazine (HP) analogues that are highly active against …