Stimuli‐Responsive antibacterial materials: molecular structures, design principles, and biomedical applications
X Wang, M Shan, S Zhang, X Chen, W Liu… - Advanced …, 2022 - Wiley Online Library
Infections are regarded as the most severe complication associated with human health,
which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic …
which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic …
Perspectives about self-immolative drug delivery systems
Self-immolative drug delivery system is one of the delivery systems, which have drawn
attention, in recent research, highlighting the improvement they generate in drug selectivity …
attention, in recent research, highlighting the improvement they generate in drug selectivity …
Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr.
XY Ding, JR Wen, WY Lin, GY Huang, Q Feng, L Duan… - Phytochemistry, 2023 - Elsevier
Two previously undescribed phloroglucinol derivatives [(±) evolephloroglucinols A and B],
five unusual coumarins [evolecoumarins A and B and (±) evolecoumarins C–E], and one …
five unusual coumarins [evolecoumarins A and B and (±) evolecoumarins C–E], and one …
Naked-eye sensing and target-guiding treatment of bacterial infection using pH-tunable multicolor luminescent lanthanide-based hydrogel
Q Zhou, X Dong, B Zhang, X Zhang, K Ou… - Journal of Colloid and …, 2022 - Elsevier
In this work, a pH-tunable multicolor luminescent lanthanide-based hydrogel (CS/DEX/CP)
was prepared based on lanthanide coordination polymer (CP), dextran aldehyde (DEX) and …
was prepared based on lanthanide coordination polymer (CP), dextran aldehyde (DEX) and …
Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections
T Li, X He, W Tao, R Zhang, Q He, H Gong, Y Liu… - European Journal of …, 2024 - Elsevier
Infections caused by drug-resistant bacteria have become a new challenge in infection
treatment, gravely endangering public health. Chloramphenicol (CL) is a well-known …
treatment, gravely endangering public health. Chloramphenicol (CL) is a well-known …
A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides
E Ermini, A Brai, E Cini, F Finetti, G Giannini… - Chemical …, 2024 - pubs.rsc.org
A stimuli-sensitive linker is one of the indispensable components of prodrugs for cancer
therapy as it covalently binds the drug and releases it upon external stimulation at the …
therapy as it covalently binds the drug and releases it upon external stimulation at the …
Fluoroquinolones' biological activities against laboratory microbes and cancer cell lines
Development of novel derivatives to rein in and fight bacteria have never been more
demanding, as microbial resistance strains are alarmingly increasing. A multitude of new …
demanding, as microbial resistance strains are alarmingly increasing. A multitude of new …
Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells
S Wang, X Wu, Y Zhang, D Zhang, B Xie… - Organic & …, 2021 - pubs.rsc.org
Hypoxia is a pathological hallmark of solid tumors. Detection of hypoxia is therefore of great
interest for tumor diagnosis and treatment. As a well-established biomarker of hypoxia …
interest for tumor diagnosis and treatment. As a well-established biomarker of hypoxia …
Site-Specific Antimicrobial Activity of a Dual-Responsive Ciprofloxacin Prodrug
CL Ross, A Lawer, KJ Sircombe, D Pletzer… - Journal of Medicinal …, 2024 - ACS Publications
Bacterial infections create distinctive microenvironments with a unique mix of metabolites
and enzymes compared with healthy tissues that can be used to trigger the activation of …
and enzymes compared with healthy tissues that can be used to trigger the activation of …
Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation
It is of great importance to develop new strategies to combat antibiotic resistance. Our lab
has discovered halogenated phenazine (HP) analogues that are highly active against …
has discovered halogenated phenazine (HP) analogues that are highly active against …