Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Background In 2003, following a workshop at the National Institutes of Health, the
International Restless Legs Syndrome Study Group (IRLSSG) developed updated …

Background Brain iron deficiency has been implicated in the pathophysiology of RLS, and
current RLS treatment guidelines recommend iron treatment when peripheral iron levels are …

Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …

A Task Force was established by the International Restless Legs Syndrome Study Group
(IRLSSG) in conjunction with the European Restless Legs Syndrome Study Group …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
and may frequently be complicated by sleep disorders. Insomnia and obstructive sleep …

Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …

Research in sleep medicine over the last decades has involved a broad variety of sleep
disorders in both men and women. Gender differences have been identified in sleep …

Background Opioids are a potential new treatment for severe restless legs syndrome. We
investigated the efficacy and safety of a fixed-dose combination of prolonged release …