Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

In vitro generation of functional gametes is a promising approach for treating infertility,
although faithful replication of meiosis has proven to be a substantial obstacle to deriving …

We sequenced more than 52,500 single cells from embryonic day 11.5 (E11. 5)
postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The complex morphology of the Sertoli cells and their interactions with germ cells has been
a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years …

In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …