Drug treatments for covid-19: living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, D Zeraatkar, E Kum… - bmj, 2020 - bmj.com
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Intensive care management of patients with COVID-19: a practical approach

LA Hajjar, IBSS Costa, SI Rizk, B Biselli… - Annals of Intensive …, 2021 - Springer
Abstract SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is
responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the …

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

VC Veiga, JAGG Prats, DLC Farias, RG Rosa… - bmj, 2021 - bmj.com
Objective To determine whether tocilizumab improves clinical outcomes for patients with
severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial …

The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19

PC Robinson, DFL Liew, JW Liew, C Monaco… - Med, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) currently has few effective treatments.
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …

Multisystem inflammatory syndrome in children (MIS-C)

JM Patel - Current allergy and asthma reports, 2022 - Springer
Abstract Purpose of Review The novel coronavirus disease 2019 (COVID-19) is caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed into a …

[HTML][HTML] Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

H Harb, M Benamar, PS Lai, P Contini, JW Griffith… - Immunity, 2021 - cell.com
A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

M Reyes, MR Filbin, RP Bhattacharyya… - Science translational …, 2021 - science.org
Bacterial sepsis and severe COVID-19 share similar clinical manifestations and are both
associated with dysregulation of the myeloid cell compartment. We previously reported an …

Effect of high versus low dose of dexamethasone on clinical worsening in patients hospitalised with moderate or severe COVID-19 pneumonia: an open-label …

M Taboada, N Rodríguez, PM Varela… - European …, 2022 - Eur Respiratory Soc
Background Low-dose dexamethasone demonstrated clinical improvement in patients with
coronavirus disease 2019 (COVID-19) needing oxygen therapy; however, evidence on the …

Influenza infection, SARS, MERS and COVID-19: cytokine storm–the common denominator and the lessons to be learned

VA Ryabkova, LP Churilov, Y Shoenfeld - Clinical Immunology, 2021 - Elsevier
The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus
infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin …

Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion

A Mazzoni, L Salvati, L Maggi, F Annunziato… - Seminars in …, 2021 - Elsevier
One and half year following the occurrence of COVID-19 pandemic, significant efforts from
laboratories all over the world generated a huge amount of data describing the prototypical …