Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

Arachidonoyl ethanolamide (anandamide) is an endogenous amide of arachidonic acid and
an important signaling mediator of the endocannabinoid system. Given its numerous roles in …

Exposure to adverse rearing environments including institutional deprivation and severe
childhood abuse is associated with an increased risk for mental and physical health …

CYP2D6, one of the major cytochrome P450 isoforms present in the human brain, is
associated with the incidence and prevalence of central nervous system (CNS) diseases …

Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the
endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are …

Highlights•Brain P450 enzymes constitute an extra-hepatic line of drug metabolism.•P450s
expressed in brain cells contribute to neurotoxicity or neuroprotection.•Neurovascular P450 …

Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug
discovery and development. It is now time to fully rethink the biological functions of drug …