The paradoxical roles of orphan nuclear receptor 4A (NR4A) in cancer
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection
SL Hammond, AN Leek, EH Richman, RB Tjalkens - PloS one, 2017 - journals.plos.org
The non-pathogenic parvovirus, adeno-associated virus (AAV), is an efficient vector for
transgene expression in vivo and shows promise for treatment of brain disorders in clinical …
transgene expression in vivo and shows promise for treatment of brain disorders in clinical …
Nuclear receptor 4A (NR4A) family–orphans no more
S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
Inflammatory activation of microglia and astrocytes in manganese neurotoxicity
RB Tjalkens, KA Popichak, KA Kirkley - Neurotoxicity of Metals, 2017 - Springer
Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early
as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1: 41–42, 1837). Extensive research …
as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1: 41–42, 1837). Extensive research …
Molecular insights into NR4A2 (Nurr1): an emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
R Rodríguez-Calvo, M Tajes… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Prolonged inflammatory response contributes to the pathogenesis of chronic
disease-related disturbances. Among nuclear receptors (NRs), the orphan NR4A subfamily …
disease-related disturbances. Among nuclear receptors (NRs), the orphan NR4A subfamily …
Nurr1‐based therapies for Parkinson's disease
Previous studies have documented that orphan nuclear receptor Nurr1 (also known as NR
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
Abstract Prokineticin-2 (PK2), a recently discovered secreted protein, regulates important
physiological functions including olfactory biogenesis and circadian rhythms in the CNS …
physiological functions including olfactory biogenesis and circadian rhythms in the CNS …