Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

All organisms must sense and respond to their external environments, and this signal
transduction often involves second messengers such as cyclic nucleotides. One such …

Lysosomes are cellular organelles primarily involved in degradation and recycling
processes. During lysosomal exocytosis, a Ca 2+-regulated process, lysosomes are docked …

Plasma membrane wounds are repaired by a mechanism involving Ca 2+-regulated
exocytosis. Elevation in intracellular [Ca 2+] triggers fusion of lysosomes with the plasma …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Trypanosoma cruzi, the causative agent of Chagas′ disease, which affects a large number
of individuals in Central and South America, is transmitted to vertebrate hosts by blood …

▪ Abstract Many metazoan cells inhabit mechanically stressful environments and,
consequently, their plasma membranes are frequently disrupted. Survival requires that the …

Induction of macrophage necrosis is a strategy used by virulent Mycobacterium tuberculosis
(Mtb) to avoid innate host defense. In contrast, attenuated Mtb causes apoptosis, which limits …

Intracellular parasitism has arisen only a few times during the long ancestry of protozoan
parasites including in diverse groups such as microsporidians, kinetoplastids, and …

Regulated secretion has been traditionally regarded as a specialized process present in
only a few cell types. Similarly, the secretory lysosomes of hematopoietic cells have been …