Cytokine imbalance as a biomarker of intervertebral disk degeneration

NA Shnayder, AV Ashhotov, VV Trefilova… - International Journal of …, 2023 - mdpi.com
The intervertebral disk degeneration (IDD) and its associated conditions are an important
problem in modern medicine. The onset of IDD may be in childhood and adolescence in …

The role of the complement system in disc degeneration and Modic changes

I Heggli, GQ Teixeira, JC Iatridis… - JOR …, 2024 - Wiley Online Library
Disc degeneration and vertebral endplate bone marrow lesions called Modic changes are
prevalent spinal pathologies found in chronic low back pain patients. Their …

Does vitamin K2 influence the interplay between diabetes mellitus and intervertebral disc degeneration in a rat model?

M Mahmoud, M Kokozidou, C Gögele, C Werner… - Nutrients, 2023 - mdpi.com
Intervertebral disc (IVD) degeneration is a common cause of low back pain in diabetes
mellitus type 2 (T2DM) patients. Its pathogenesis and the vitamin (vit.) K2 influence on this …

Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation

JH Shin, SH Park, H Cho, JH Kim, H Choi - Scientific reports, 2022 - nature.com
Adipokine human Resistin (hResistin), is known to be associated with insulin resistance and
secrete low-grade pro-inflammatory cytokines in obesity. Although studies on low-grade …

Diagnostic model based on key autophagy-related genes in intervertebral disc degeneration

Y Wang, Z Wang, Y Tang, Y Chen, C Fang, Z Li… - BMC Musculoskeletal …, 2023 - Springer
Background Current research on autophagy is mainly focused on intervertebral disc tissues
and cells, while there is few on human peripheral blood sample. therefore, this study …

Terminal complement activation is induced by factors released from endplate tissue of disc degeneration patients and stimulates expression of catabolic enzymes in …

A Kuhn, J Riegger, GQ Teixeira, M Huber-Lang… - Cells, 2023 - mdpi.com
Terminal complement complex (TCC) deposition was identified in human degenerated
discs. To clarify the role of terminal complement activation in disc degeneration (DD), we …

Reactive response of peripheral blood neutrophils of school-age adolescents with scoliosis

D Dychko, E Dychko, O Nekhanevych… - … en educación física …, 2024 - dialnet.unirioja.es
La escoliosis afecta negativamente a la salud física y mental de niños y adolescentes. La
deformidad escoliótica se desarrolla más rápidamente durante el período de crecimiento y …

Identification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis

Y Li, R Huang, J Ye, X Han, T Meng, D Song… - BMC Musculoskeletal …, 2024 - Springer
Background Intervertebral disc degeneration (IVDD) is a common degenerative condition
leading to abnormal stress distribution under load, causing intervertebral stenosis, facet joint …

Interleukin-1β more than mechanical loading induces a degenerative phenotype in human annulus fibrosus cells, partially impaired by anti-proteolytic activity of …

RM Gonçalves, T Saggese, Z Yong… - … in Bioengineering and …, 2022 - frontiersin.org
Mesenchymal stem/stromal cell (MSC)–based therapies for low back pain and intervertebral
disc (IVD) degeneration have been emerging, despite the poor knowledge of their full …

Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures

F Widmayer, C Neidlinger-Wilke, F Witz… - International Journal of …, 2023 - mdpi.com
Postmenopausal women are at an increased risk for intervertebral disc degeneration,
possibly due to the decrease in oestrogen levels. Low-magnitude, high-frequency vibration …