Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest
that∼ 37% of human tumors have undergone a genome-doubling event during their …

Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To
support this malignant phenotype, cells acquire molecular alterations that abrogate or …