[HTML][HTML] Zinc and oxidative stress: current mechanisms

DN Marreiro, KJC Cruz, JBS Morais, JB Beserra… - Antioxidants, 2017 - mdpi.com
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules,
contributing to the oxidative damage of cells and tissues. This consequently contributes to …

Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages

L Staurengo-Ferrari, S Badaro-Garcia… - Frontiers in …, 2019 - frontiersin.org
Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

HQ Ju, YX Lu, QN Wu, J Liu, ZL Zeng, HY Mo, Y Chen… - Oncogene, 2017 - nature.com
Abstract Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates
NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species …

COVID-19: A redox disease—What a stress pandemic can teach us about resilience and what we may learn from the reactive species interactome about its treatment

AF Cumpstey, AD Clark, J Santolini… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus
causing coronavirus disease 2019 (COVID-19), affects every aspect of human life by …

Relevance of Nrf2 and heme oxygenase-1 in articular diseases

MJ Alcaraz, ML Ferrándiz - Free Radical Biology and Medicine, 2020 - Elsevier
Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

Neurodegeneration in ataxia‐telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

KR Choy, DJ Watters - Developmental Dynamics, 2018 - Wiley Online Library
Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes,
immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the …

[HTML][HTML] Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

G Manda, E Milanesi, S Genc, CM Niculite… - Free Radical Biology …, 2022 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease with an important inflammatory
component accompanied by deregulated redox-dependent signaling pathways that are …

Modulation of inflammatory and oxidative stress biomarkers due to dexamethasone exposure in chicken splenocytes

S Ambwani, R Dolma, R Sharma, A Kaur… - Veterinary Immunology …, 2023 - Elsevier
Dexamethasone (DEXA) is a potent corticosteroid, commonly used for treating inflammatory,
hypersensitive and allergic conditions. It is administered to birds with tumours. Many studies …

Discovery of therapeutics targeting oxidative stress in autosomal recessive cerebellar ataxia: a systematic review

SY Lew, MWL Phang, PS Chong, J Roy, CH Poon… - Pharmaceuticals, 2022 - mdpi.com
Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of rare
neurodegenerative inherited disorders. The resulting motor incoordination and progressive …

The standardized extract of Centella asiatica and its fractions exert antioxidative and anti-neuroinflammatory effects on microglial cells and regulate the Nrf2/HO-1 …

A Hambali, NA Jusril, NF Md Hashim… - Journal of …, 2024 - content.iospress.com
Background: Neuroinflammation and oxidative stress can aggravate the progression of
Alzheimer's disease (AD). Centella asiatica has been traditionally consumed for memory …