[HTML][HTML] Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

R Gencheva, Q Cheng, ESJ Arner - Free Radical Biology and Medicine, 2022 - Elsevier
Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy

H Zhang, Y Peng, L Zhuo, Y Wang, G Zeng… - European Journal of …, 2022 - Elsevier
Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β
(Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target …

Observations into quantum simulation, spectroscopy, electronic properties, pharmacokinetics and molecular docking analysis of lawsone against breast cancer

K Chandran, A Zochedh, AB Sultan… - Journal of Molecular …, 2023 - Elsevier
In this current investigation, structural and spectroscopic characteristics of the Lawsone (2-
hydroxy-1, 4-napthoquinone) molecule was examined by density functional theory (DFT) …

[HTML][HTML] Neuroprotective role of plumbagin on eye damage induced by high-sucrose diet in adult fruit fly Drosophila melanogaster

E Catalani, S Del Quondam, K Brunetti… - Biomedicine & …, 2023 - Elsevier
The natural compound plumbagin has a wide range of pharmacological and potential
therapeutic activities, although its role in neuroretina degeneration is unknown. Here we …

Chemopreventive Effects of Onosma mutabilis against Azoxymethane-Induced Colon Cancer in Rats via Amendment of Bax/Bcl-2 and NF-κB Signaling Pathways

AA Jabbar, IAA Ibrahim, FO Abdullah, KF Aziz… - Current Issues in …, 2023 - mdpi.com
Onosma species (Boraginaceae) are well known as medicinal plants due to their wide range
of pharmaceutical potential. The present study aims to investigate the anticancer (in vitro) …

Plumbagin, a natural compound with several biological effects and anti-inflammatory properties

G Petrocelli, P Marrazzo, L Bonsi, F Facchin, F Alviano… - Life, 2023 - mdpi.com
Phytochemicals from various medicinal plants are well known for their antioxidant properties
and anti-cancer effects. Many of these bioactive compounds or natural products have …

Multidrug Resistant Enteric Bacteria from Cancer Patients Admitted in Douala Laquintinie Hospital, Littoral Region of Cameroon

MF Kengne, OD Tsobeng, BST Dadjo… - Canadian Journal of …, 2024 - Wiley Online Library
Patients with cancer have weakened immune systems, making them more vulnerable to
infections. This study was carried out to determine the bacterial origins of enteric disorders in …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

Evaluation of 1, 4-naphthoquinone derivatives as antibacterial agents: Activity and mechanistic studies

Z Liu, Z Shen, S Xiang, Y Sun, J Cui, J Jia - Frontiers of Environmental …, 2023 - Springer
The diverse and large-scale application of disinfectants posed potential health risks and
caused ecological damage during the 2019-nCoV pandemic, thereby increasing the …

Natural Products for pesticides discovery: structural diversity derivation and biological activities of naphthoquinones plumbagin and juglone

K Wang, B Wang, H Ma, Z Wang, Y Liu, Q Wang - Molecules, 2023 - mdpi.com
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult
to control. Natural products are an important source for the discovery of new pesticides. In …