Wheat ATIs: characteristics and role in human disease

S Geisslitz, P Shewry, F Brouns, AHP America… - Frontiers in …, 2021 - frontiersin.org
Amylase/trypsin-inhibitors (ATIs) comprise about 2–4% of the total wheat grain proteins and
may contribute to natural defense against pests and pathogens. However, they are currently …

Allergenicity of wheat protein in diet: Mechanisms, modifications and challenges

M Liu, J Huang, S Ma, G Yu, A Liao, L Pan… - Food research …, 2023 - Elsevier
Wheat is widely available in people's daily diets. However, some people are currently
experiencing IgE-mediated allergic reactions to wheat-based foods, which seriously impact …

Intestinal exposure to food-derived protease inhibitors: digestion physiology-and gut health-related effects

A Kårlund, I Paukkonen, C Gómez-Gallego… - Healthcare, 2021 - mdpi.com
Plant-derived protease inhibitors (PI), such as Bowman-Birk inhibitors and Kunitz-type
inhibitors, have been suggested to negatively affect dietary protein digestion by blocking the …

Wheat amylase/trypsin inhibitors (ATIs): occurrence, function and health aspects

S Geisslitz, P Weegels, P Shewry, V Zevallos… - European Journal of …, 2022 - Springer
Amylase/trypsin inhibitors (ATIs) are widely consumed in cereal-based foods and have been
implicated in adverse reactions to wheat exposure, such as respiratory and food allergy, and …

Comparative quantitative LC–MS/MS analysis of 13 amylase/trypsin inhibitors in ancient and modern Triticum species

S Geisslitz, CFH Longin, P Koehler, KA Scherf - Scientific reports, 2020 - nature.com
Amylase/trypsin inhibitors (ATIs) are major wheat allergens and they are also implicated in
causing non-celiac gluten sensitivity and worsening other inflammatory conditions. With only …

Application of mass spectrometry-based proteomics to barley research

M Bahmani, CE O'Lone, A Juhász… - Journal of Agricultural …, 2021 - ACS Publications
Barley (Hordeum vulgare) is the fourth most cultivated crop in the world in terms of
production volume, and it is also the most important raw material of the malting and brewing …

Comprehensive proteome analysis of bread deciphering the allergenic potential of bread wheat, spelt and rye

J Zimmermann, P Hubel, J Pfannstiel, M Afzal… - Journal of …, 2021 - Elsevier
Abstract Background/Objectives Cereal products like flour and bread are known to trigger
diseases such as wheat allergy, celiac disease and non-celiac wheat sensitivity (NCWS) …

Breeding from 1891 to 2010 did not increase the content of amylase/trypsin-inhibitors in wheat (Triticum aestivum)

S Geisslitz, D Pronin, M Neerukonda, V Curella… - npj Science of …, 2023 - nature.com
The prevalence of hypersensitivities towards wheat has increased in the last decades. Apart
from celiac disease these include allergic and other inflammatory reactions summarized …

Comprehensive characterization and relative quantification of α-amylase/trypsin inhibitors from wheat cultivars by targeted HPLC-MS/MS

ST Sagu, L Zimmermann, E Landgräber, T Homann… - Foods, 2020 - mdpi.com
The α-amylase/trypsin inhibitors (ATIs) are discussed as being responsible for non-celiac
wheat sensitivity (NCWS), besides being known as allergenic components for baker's …

Hybrid QconCAT-based targeted absolute and data-independent acquisition-based label-free quantification enables in-depth proteomic characterization of wheat …

M Sielaff, V Curella, M Neerukonda… - Journal of Proteome …, 2021 - ACS Publications
Wheat amylase/trypsin inhibitors (ATIs) have gained significant relevance as inducers of
intestinal and extra-intestinal inflammation. In this study, we present a novel hybrid data …