Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review,
we discuss the potential to target cholesterol metabolism as a new strategy for treating …

Glioblastoma (GBM) is the most lethal malignant tumor in the central nervous system, with a
median survival of only 14 months. Cholesterol, which is the main component of cell …

The fruit of Garcinia mangostana (mangosteen) is known in ancient traditional Asian
medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer activities …

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the
mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but …

3-hydroxytyrosol (HT) is the main phenolic compound found in olive oil with known
antioxidant, anti-inflammatory, and antimicrobial properties in several dermatological …

Protein prenylation is a critical mediator in several diseases including cancer and acquired
immunodeficiency syndrome (AIDS). Therapeutic intervention has focused primarily on …

Cancer cell stress induced by cytotoxic agents promotes antitumor immune response. Here,
we observed that N6‐isopentenyladenosine (iPA), an isoprenoid modified adenosine with a …

Simvastatin, an inhibitor of 3‑hydroxy‑3-methylglutaryl‑coenzyme A reductase, is been used
in the clinic due to its pleiotropic effects, such as breast cancer, prostate cancer, pancreatic …

Glioblastoma multiforme (GB) is one of the most aggressive tumors. Despite continuous
efforts to improve its clinical management, there is still no strategy to avoid a rapid and fatal …

N6-Isopentenyladenosine (i6A) is a naturally occurring modified nucleoside displaying in
vitro and in vivo antiproliferative and pro-apoptotic properties. In our previous studies …