Vaccine adjuvants interact with the immune system, to increase the potency of vaccine
antigens. Many of the adjuvants currently available were developed with little understanding …

The innate immune system plays an essential role in the host's first line of defense against
microbial invasion, and involves the recognition of distinct pathogen-associated molecular …

Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6
(H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their …

Cord factor, also called trehalose-6, 6′-dimycolate (TDM), is a potent mycobacterial
adjuvant. We herein report that the C-type lectin MCL (also called Clec4d) is a TDM receptor …

Cytotoxic T lymphocyte (CTL) responses targeting specific HIV proteins, in particular Gag,
have been associated with relative control of viral replication in vivo. However, Gag-specific …

ABSTRACT T follicular helper (Tfh) cells are specialized providers of cognate B cell help,
which is important in promoting the induction of high-affinity antibody production in germinal …

Staphylococcus aureus infections are a major public health issue, and a vaccine is urgently
needed. Despite a considerable promise in preclinical models, all vaccines tested thus far …

Recent innovations and developments in nanotechnology have revolutionized cancer
therapeutics. Engineered nanomaterials are the current workhorses in the emerging field of …

Mycobacterium tuberculosis (Mtb) continues to be a major health threat worldwide, and the
development of Mtb vaccines could play a pivotal role in the prevention and control of this …

Self-amplifying RNA (saRNA) is well suited as a vaccine platform against chlamydia, as it is
relatively affordable and scalable, has been shown to induce immunity against multivalent …