TEER measurement techniques for in vitro barrier model systems
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
Impact of Culture Medium on Cellular Interactions in in vitro Co-culture Systems
Co-culturing of cells in in vitro tissue models is widely used to study how they interact with
each other. These models serve to represent a variety of processes in the human body such …
each other. These models serve to represent a variety of processes in the human body such …
Interconnected microphysiological systems for quantitative biology and pharmacology studies
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ
function through use of specialized culture microenvironments, including 3D matrices and …
function through use of specialized culture microenvironments, including 3D matrices and …
Microengineered multi‐organoid system from hiPSCs to recapitulate human liver‐islet axis in normal and type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is
characterized by the dynamic interplay among different organs. The increasing incidence of …
characterized by the dynamic interplay among different organs. The increasing incidence of …
Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies
S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
Current practices in drug development have led to therapeutic compounds being approved
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
Many drugs have progressed through preclinical and clinical trials and have been available–
for years in some cases–before being recalled by the FDA for unanticipated toxicity in …
for years in some cases–before being recalled by the FDA for unanticipated toxicity in …
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs
We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …
Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …
biomimetic principles to create key aspects of living organs faithfully, including critical …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …