The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

This article presents the revised consensus criteria for the diagnosis of frontotemporal
dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research …

Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently
limited. However, recent studies show that almost all cases of ALS, as well as tau-negative …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Although amyotrophic lateral sclerosis (ALS) was identified as a neurological condition 150
years ago, risk factors related to the onset and progression of ALS remain largely unknown …

The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects
motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been …

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …