The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

Angiotensin converting enzyme 2 (ACE2) is a main receptor for SARS-CoV-2 entry to the
host cell. ACE2 is one of the key enzymes in renin-angiotensin system and plays a vital role …

The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

Fructose intake is linked with the increasing prevalence of insulin resistance and there is
now evidence for a specific insulin-resistant cardiomyopathy. The aim of this study was to …

Further research on the contribution of the Ang-(1–7)/ACE2/Mas axis to cardiovascular
pathology will lead to the development of new pharmacological approaches resulting in the …

A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been
attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have …

Background. The angiotensin-(1-7) is a new component of the renin-angiotensin system, the
product of the degradation of angiotensin II and its functional antagonist, but its role in …