Genetic predisposition and chromosome instability in neuroblastoma

GP Tonini, M Capasso - Cancer and Metastasis Reviews, 2020 - Springer
Neuroblastoma (NB) is a pediatric tumor of embryonic origin. About 1–2% of all NBs are
familial cases, and genetic predisposition is suspected for the remaining cases. During the …

Recent insights into the biology of neuroblastoma

G Schleiermacher, I Janoueix‐Lerosey… - … journal of cancer, 2014 - Wiley Online Library
Neuroblastoma (NB) is an embryonal tumor of the sympathetic nervous system which
accounts for 8–10% of pediatric cancers. It is characterized by a broad spectrum of clinical …

Deep learning-based multi-omics data integration reveals two prognostic subtypes in high-risk neuroblastoma

L Zhang, C Lv, Y Jin, G Cheng, Y Fu, D Yuan… - Frontiers in …, 2018 - frontiersin.org
High-risk neuroblastoma is a very aggressive disease, with excessive tumor growth and
poor outcomes. A proper stratification of the high-risk patients by prognostic outcome is …

Neuroblastoma (Peripheral neuroblastic tumours)

R Luksch, MR Castellani, P Collini… - Critical reviews in …, 2016 - Elsevier
Peripheral neuroblastic tumours (PNTs), a family of tumours arising in the embryonal
remnants of the sympathetic nervous system, account for 7–10% of all tumours in children. In …

The challenge of defining “ultra‐high‐risk” neuroblastoma

DA Morgenstern, R Bagatell, SL Cohn… - Pediatric Blood & …, 2019 - Wiley Online Library
Given the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to
determining appropriate treatment. Historically, most patients with high‐risk neuroblastoma …

Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis

K Metze - Expert review of molecular diagnostics, 2013 - Taylor & Francis
Fractal characteristics of chromatin, revealed by light or electron microscopy, have been
reported during the last 20 years. Fractal features can easily be estimated in digitalized …

17q gain in neuroblastoma: A review of clinical and biological implications

V Mlakar, I Dupanloup, F Gonzales… - Cancers, 2024 - mdpi.com
Simple Summary Neuroblastoma (NB) is the most frequent solid extracranial tumor in
children and the most frequently diagnosed cancer during infancy. A genetic modification, a …

Rho-associated kinase is a therapeutic target in neuroblastoma

C Dyberg, S Fransson, T Andonova… - Proceedings of the …, 2017 - National Acad Sciences
Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and
is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors …

The role of surgery in high-risk neuroblastoma

AL Ryan, A Akinkuotu, A Pierro… - Journal of pediatric …, 2020 - journals.lww.com
Although intensive multimodal treatment has improved outcomes for patients with high-risk
neuroblastoma, the specific role of primary tumor resection remains controversial. Many …

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

P Fusco, B Parisatto, E Rampazzo, L Persano… - BMC cancer, 2019 - Springer
Background Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system.
Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from …