[HTML][HTML] Biological roles of RNA m5C modification and its implications in Cancer immunotherapy

H Song, J Zhang, B Liu, J Xu, B Cai, H Yang… - Biomarker …, 2022 - Springer
Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …

RNA modifications in cancer

Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Dynamic transcriptomic m5C and its regulatory role in RNA processing

YS Chen, WL Yang, YL Zhao… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract RNA 5‐methylcytosine (m5C) is a prevalent RNA modification in multiple RNA
species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs …

[HTML][HTML] 5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

[HTML][HTML] Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

[HTML][HTML] The RNA methyltransferase NSUN2 and its potential roles in cancer

A Chellamuthu, SG Gray - Cells, 2020 - mdpi.com
5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also
found increasingly in a plethora of RNA species, predominantly transfer RNAs, but …

[HTML][HTML] The role of RNA m5C modification in cancer metastasis

Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

[HTML][HTML] Multiple links between 5-methylcytosine content of mRNA and translation

U Schumann, HN Zhang, T Sibbritt, A Pan, A Horvath… - BMC biology, 2020 - Springer
Abstract Background 5-Methylcytosine (m 5 C) is a prevalent base modification in tRNA and
rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it …

[HTML][HTML] Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance

G Guo, K Pan, S Fang, L Ye, X Tong, Z Wang… - … Therapy-Nucleic Acids, 2021 - cell.com
5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …

Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation

W Dai, A Li, NJ Yu, T Nguyen, RW Leach… - Nature chemical …, 2021 - nature.com
Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a
major gap in our understanding of the RNA chemistry present in biological systems. Here we …