Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy
production. Cells adapt to varying oxygen levels through intricate response systems …

Radiotherapy and chemotherapy are two famous modalities in tumor‐targeted therapy that
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …

With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …

Reactive oxygen species (ROS), which are a byproduct of oxidative metabolism, serve as
signaling molecules in a number of physiological settings. However, if their levels are not …

Chemical proteomics encompasses novel drug target deconvolution methods in which
compound modification is not required. Herein we use Thermal Proteome Profiling …

Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …

Mass spectrometry imaging (MSI) is an established analytical tool capable of defining and
understanding complex tissues by determining the spatial distribution of biological …

Oxidative stress and its end-products, such as 4-hydroxynonenal (HNE), initiate activation of
the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)/Kelch Like ECH Associated Protein …

Anticancer drugs that target cellular antioxidant systems have recently attracted much
attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer …