Mycobacteriophages: therapeutic approach for mycobacterial infections

SK Raman, DVS Reddy, V Jain, U Bajpai, A Misra… - Drug Discovery …, 2024 - Elsevier
Tuberculosis (TB) is a significant global health threat, and cases of infection with non-
tuberculous mycobacteria (NTM) causing lung disease (NTM-LD) are rising. Bacteriophages …

[HTML][HTML] Mycobacteriophages and Their Applications

A Bonacorsi, C Ferretti, M Di Luca, L Rindi - Antibiotics, 2024 - pmc.ncbi.nlm.nih.gov
Mycobacterial infections caused by tuberculous and non-tuberculous strains pose significant
treatment challenges, especially among immunocompromised patients. Conventional …

Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles

MM Obiedallah, MA Mironov, DV Belyaev, A Ene… - Scientific Reports, 2024 - nature.com
The treatment of tuberculosis is still a challenging process due to the widespread of
pathogen strains resistant to antibacterial drugs, as well as the undesirable effects of anti …

Construing the function of N‐terminal domain of D29 mycobacteriophage LysA endolysin in phage lytic efficiency and proliferation

R Gangakhedkar, V Jain - Molecular Microbiology, 2024 - Wiley Online Library
Endolysins produced by bacteriophages hydrolyze host cell wall peptidoglycan to release
newly assembled virions. D29 mycobacteriophage specifically infects mycobacteria …

Discovery and characterization of a novel LysinB from F2 sub-cluster mycobacteriophage RitSun

R Arora, K Nadar, U Bajpai - Scientific Reports, 2024 - nature.com
The escalating antibiotic resistance in mycobacterial species poses a significant threat
globally, necessitating an urgent need to find alternative solutions. Bacteriophage-derived …

Elucidating the molecular properties and anti-mycobacterial activity of cysteine peptidase domain of D29 mycobacteriophage endolysin

R Gangakhedkar, V Jain - Journal of Virology, 2024 - journals.asm.org
Emergence of antibiotic resistance in pathogenic Mycobacterium tuberculosis (Mtb) has
elevated tuberculosis to a serious global threat, necessitating alternate solutions for its …

[HTML][HTML] Unlocking prophage potential: In silico and experimental analysis of a novel Mycobacterium fortuitum LysinB containing a peptidoglycan-binding domain

R Das, K Nadar, R Arora, U Bajpai - bioRxiv, 2024 - ncbi.nlm.nih.gov
Endolysins are highly evolved bacteriophage-encoded lytic enzymes produced to damage
the bacterial cell wall for phage progeny release. They offer promising potential as highly …

A novel LysinB from an F2 sub-cluster mycobacteriophage RitSun

R Arora, K Nadar, U Bajpai - bioRxiv, 2024 - biorxiv.org
With the growing antibiotic resistance in mycobacterial species posing a significant threat
globally, there is an urgent need to find alternative solutions. Bacteriophage-derived …

Investigation of Rhodococcus equi bacteriophages from Australian horse breeding farms

K Muscat - 2024 - ses.library.usyd.edu.au
Rhodococcus equi is the cause of pneumonia in foals and significant economic losses to the
equine industry. Alarmingly, R. equi antimicrobial resistance is rising and no vaccine is …