Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice
Background and purpose Long-term disability after stroke is common yet the mechanisms of
post-stroke recovery are far from clear. It has been suggested that Ras-related C3 botulinum …
post-stroke recovery are far from clear. It has been suggested that Ras-related C3 botulinum …
ROS/TRPA1/CGRP signaling mediates cortical spreading depression
L Jiang, D Ma, BD Grubb, M Wang - The Journal of Headache and Pain, 2019 - Springer
Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-
related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand …
related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand …
Src family kinases facilitate the crosstalk between CGRP and cytokines in sensitizing trigeminal ganglion via transmitting CGRP receptor/PKA pathway
The communication between calcitonin gene-related peptide (CGRP) and cytokines plays a
prominent role in maintaining trigeminal ganglion (TG) and trigeminovascular sensitization …
prominent role in maintaining trigeminal ganglion (TG) and trigeminovascular sensitization …
Src family kinases in the central nervous system: their emerging role in pathophysiology of migraine and neuropathic pain
L Nie, WR Ye, S Chen, D Chirchiglia… - Current …, 2021 - ingentaconnect.com
Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal
role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also …
role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also …
The transient receptor potential ankyrin type 1 plays a critical role in cortical spreading depression
The transient receptor potential ankyrin type-1 (TRPA1) channels have been proposed as a
potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine …
potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine …
[HTML][HTML] Electrophysiological effects of nicotinic and electrical stimulation of intrinsic cardiac ganglia in the absence of extrinsic autonomic nerves in the rabbit heart
E Allen, JH Coote, BD Grubb, TFC Batten, DH Pauza… - Heart rhythm, 2018 - Elsevier
Background The intrinsic cardiac nervous system is a rich network of cardiac nerves that
converge to form distinct ganglia and extend across the heart and is capable of influencing …
converge to form distinct ganglia and extend across the heart and is capable of influencing …
TRPA1-mediated Src family kinases activity facilitates cortical spreading depression susceptibility and trigeminovascular system sensitization
L Nie, L Jiang, JP Quinn, BD Grubb… - International Journal of …, 2021 - mdpi.com
Transient receptor potential ankyrin 1 (TRPA1) plays a role in migraine and is proposed as a
promising target for migraine therapy. However, TRPA1-induced signaling in migraine …
promising target for migraine therapy. However, TRPA1-induced signaling in migraine …
Sarcoma family kinase-dependent pannexin-1 activation after cortical spreading depression is mediated by NR2A-containing receptors
Cortical spreading depression (CSD) is a propagating wave of depolarization followed by
depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) …
depression of cortical activity. CSD triggers neuroinflammation via the pannexin-1 (Panx1) …
Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity
Z Huang, J Yao, L Nie, X Nie, X Xiong, S Kõks… - The Journal of …, 2024 - Springer
Abstract Background Src family kinases (SFKs) contribute to migraine pathogenesis, yet its
role in regulating photophobia behaviour, one of the most common forms of migraine …
role in regulating photophobia behaviour, one of the most common forms of migraine …
Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
Abstract Background Purinergic P2X7 receptor plays an important role in migraine
pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine …
pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine …