IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Objective To update evidence‐based recommendations for the treatment of patients with
ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA). Methods We …

Objectives To update the Assessment of SpondyloArthritis international Society (ASAS)-
EULAR recommendations for the management of axial spondyloarthritis (axSpA). Methods …

Several new treatment modalities with different mechanisms of action have been studied in
patients with Behçet's syndrome (BS). The aim of the current effort was to update the …

Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

The presence of symptom clusters, regional differences in disease expression and
similarities with, for example, Crohn's disease suggest multiple pathological pathways are …

Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …

Background Non-infectious uveitis is a potentially sight-threatening ocular disorder caused
by chronic inflammation and its complications. Therapeutic success is limited by systemic …

The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to
multiple autoimmune diseases. Identification of the genetic causes of primary …

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …